Irisin is a newly discovered (2012) proteinaceous hormone secreted by skeletal muscle in response to exercise, in both humans and mice.
Studies in mice find that small increases in the concentration of irisin in the blood cause “an increase in energy expenditure…with no change in movement or food intake”. Body weight decreased, insulin resistance—a defining characteristic of type 2 diabetes—lessened, and glucose homeostasis improved.
Crunkhorn 2012: TheNoteText
- Crunkhorn S. (2012) Metabolic disease: Exercise hormone fights metabolic disease. Nat Rev.Drug Discov. 11(3):189.