Nitrogen mustards

Nitrogen mustard is the name of a family of alkylating agents, originally developed as chemical weapons but found to have medical uses including acting as antineoplastic agents.

The family contains three compounds listed in Schedule 1 of the Chemical Weapons Convention:

• HN1: Bis(2-chloroethyl)ethylamine (538-07-8)
• HN2: Bis(2-chloroethyl)methylamine (51-75-2)
• HN3: Tris(2-chloroethyl)amine (555-77-1)

Additional nitrogen mustards used in medicine include:

• Cyclophosphamide
• Chlorambucil
• Melphalan
• Chlormethine
• Ifosfamide
• Thiotepa
• Trofosfamide
• Prednimustine