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Rosuvastatin

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Rosuvastatin, a type II statin.

Rosuvastatin, marketed as Crestor, is a type II statin used to treat high cholesterol levels (hypercholesterolemia), prevent heart attacks and strokes, and to diminish the formation of arterial plaque. It is a HMG-CoA reductase inhibitor that decreases the conversion of HMG-CoA to mevalonate, a key chemical precursor of cholesterol. It is related to other type II statins such as fluvastatin and atorvastatin.

Its official chemical IUPAC name is (E,3R,5R)-7-[4-(4-fluorophenyl)-2-(methyl-methylsulfonylamino)-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid and its chemical formula is C22H28FN3O6S.

History

Crestor brand of rosuvastatin was approved for Merck and Schering-Plough by the Food and Drug Administration in the United States with a New Drug Application (NDA) in 2003.[1] A generic version of rosuvastatin calcium with a AB Therapeutic Equivalence Code was approved for Mylan Pharma with a Abbreviated New Drug Application (ANDA) in 2010.[2] A generic version of rosuvastatin zinc with a AB Therapeutic Equivalence Code was approved for Watson Labs with a Abbreviated New Drug Application (ANDA) in 2011.[3]

External links

The most up-to-date information about Rosuvastatin and other drugs can be found at the following sites.


References

  1. Anonymous. Drugs@FDA for FDA Application No. 021366. U S Food and Drug Administration
  2. Anonymous. Drugs@FDA for FDA Application No. 079161. U S Food and Drug Administration
  3. Anonymous. Drugs@FDA for FDA Application No. 202172. U S Food and Drug Administration