Mirtazapine

Mirtazapine is a second-generation antidepressant agent.

"The clinical response of our patients underscores the usefulness of mirtazapine in the treatment of the comorbid symptoms of weight loss, insomnia, and anxiety".

Amitriptyline, mirtazapine, and paroxetine may case more weight gain than other antidepressents according to a meta-analysis.