Propranolol

In medicine, propranolol is "a widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for myocardial infarction; arrhythmia; angina pectoris; hypertension; hyperthyroidism; migraine; pheochromocytoma; and anxiety but adverse effects instigate replacement by newer drugs."

History
Propranolol was developed by Akrimax Pharms. Atenolol received approval in the United States November 13, 1967.

Generic propranolol was available October 22, 1985.

Metabolism
Propranolol is metabolized in the liver by several isoenzymes of cytochrome P-450 2D6.