Dopamine receptor

Dopamine receptors are "cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells."

D1-like receptors
These receptors stimulate adenylate cyclase.

D2-like receptors
These receptors inhibit adenylate cyclase.

Dopamine D2 receptors
Agonists, such as metoclopramide, are used as antiemetics.

Antagonists, such as risperidone and haloperidol, are used to treat schizophrenia.

Blockade of the D2 receptors, which may be predisposed by genetic polymorphisms of the allele, may cause neuroleptic malignant syndrome.

D3 receptors
Agonists of D3, especially nonergot agonists such as pramipexole and ropinirole, may be used to treat Parkinonism and restless legs syndrome.

D4 receptors
Novelty seeing personality trait may be related to polymorphisms in the dopamine receptor D4 that affects dopamine activity in the tuberoinfundibular dopaminergic system.