User:Lauren Beaton/Sandbox

So far in Dopamine article:

Attention deficit hyperactivity disorder
ADHD may result from reduced inhibitory dopamine transmission in the midbrain. This may be due to an increase in dopamine plasma membrane transport protein density which may remove dopamine from the synapse too quickly.

Drug abuse
The rewarding effects of amphetamines and cocaine are due to dopamine activity. Cocaine increases monoamine levels by binding to serotonin (5-HT), norepinephrine (NE), and dopamine (DA) catecholamine plasma membrane transport proteins. This blockade prevents the reuptake of neurotransmitters, thus increasing the amount available at the synapse to bind to the post synaptic cell. In contrast to amphetamine, a similar psychomotor stimulant, cocaine is a dopamine uptake inhibitor and does not stimulate DA release. Cocaine's rewarding effects come primarily from increased activity in the mesolimbic dopamine pathway.

Novelty Seeking Personality Trait
Novelty seeing personality trait may be related to polymorphisms in the dopamine receptor D4 that affects dopamine activity in the tuberoinfundibular dopaminergic system.

Schizophrenia
The dopamine hypothesis proposes that schizophrenia is in part due to excessive dopaminergic activity.

The third version of the dopamine hypothesis was indroduced in May 2009 by Howes & Kapur. This is important because ...