Proton pump inhibitor

In medicine, proton pump inhibitors (PPI) are medications that "inhibit H(+)-K(+)-exchanging atpase. They are used as anti-ulcer agents and sometimes in place of histamine H2 antagonists for gastroesophageal reflux." They are also used as part of curative therapy for Helicobacter pylori, in combination with antibiotics.

Metabolism
Proton pump inhibitors are metabolized by the CYP2C19 isoenzyme of cytochrome P-450. This may be less true for pantoprazole and esomeprazole.

Adverse effects
Proton pump inhibitors may be associated with spontaneous bacterial peritonitis. Recent starting of these drugs may also be associated with pneumonia acquired in the community or hospital. These drugs may be associated with Clostridium difficile diarrhea, and fractures.

Starting proton pump inhibitors in healthy volunteers may induce acid-related symptoms PPIs are stopped This is problematic considering how often PPIs are incorrectly prescribed.

Drug interactions
Proton pump inhibitors (especially inhibitors other than pantoprazole ), which are metabolized by the CYP2C19 isoenzyme of cytochrome P-450, may or may not increase adverse cardiac events when given to patients taking clopidogrel for coronary heart disease.