Angioedema

In medicine and immunology, angioedema is "swelling involving the deep dermis, subcutaneous, or submucosal tissues, representing localized edema. Angioedema often occurs in the face, lips, tongue, and larynx."

Hereditary angioedema (Hereditary C1 esterase inhibitor deficiency)
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Acquired deficiency is characterized by low levels of complement C1q.

Acquired angioedema (Acquired C1 esterase inhibitor deficiency)
"Acquired C1 esterase inhibitor deficiency is a rare condition associated with autoimmune or low-grade lymphoproliferative disorder."


 * Type I disease is associated with lymphoproliferative disorders.
 * Type II disease is associated with autoantibodies and monoclonal gammopathies.

Acquired deficiency is characterized by low levels of complement C1q.

Diagnosis
Angioedema due to deficiency of complement C1 inhibitor protein may manifest reduced d-dimer levels, especially during attacks.