Thrombotic thrombocytopenic purpura

In medicine and hematology, thrombotic thrombocytopenic purpura (TTP) is "an acquired, congenital, or familial disorder caused by platelet aggregation with thrombosis in terminal arterioles and capillaries. Clinical features include thrombocytopenia; hemolytic anemia; azotemia; fever; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as renal failure."

Patients with primary TTP may have low von Willebrand factor-degrading protease (ADAMTS13 protein) which allows thrombi due to von Willebrand factor (vWF).