Autoimmune polyendocrinopathy

In medicine, autoimmune polyendocrinopathies, also called polyglandular autoimmune syndrome or autoimmune polyendocrine syndrome (APS), are "autoimmune diseases affecting multiple endocrine organs.

Classification
"Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (candidiasis, chronic mucocutaneous)." "Type II exhibits any combination of adrenal insufficiency (addison's disease), lymphocytic thyroiditis (thyroiditis, autoimmune;), hypoparathyroidism; and gonadal failure." Type II is also called Schmidt's Syndrome. IPEX

Etiology/cause
"In both types organ-specific antibodies against a variety of endocrine glands have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present."

Notable cases
American President John F. Kennedy may have had this syndrome.