Diabetic nephropathy

In medicine, diabetic nephropathies, also called Kimmelstiel-Wilson Disease and glomerulosclerosis, are "kidney injuries associated with diabetes mellitus and affecting kidney glomerulus; arterioles; kidney tubules; and the interstitium. Clinical signs include persistent proteinuria, from microalbuminuria progressing to albuminuria of greater than 300 mg/24 h, leading to reduced glomerular filtration rate and end-stage renal disease."

Prevention
Telmisartan, an angiotensin II type 1 receptor blocker, slows the increase in albuminuria but may worsen the serum creatinine and glomerular filtration rate.