Antineoplastic agent/Related Articles

Ethylene imines
ATC/DDD group L01AC.

Nitrosoureas
ATC/DDD group L01AD.

Epoxides
ATC/DDD group L01AG.

Other alkylating agents
ATC/DDD group L01AX.

Antimetabolites
ATC/DDD group L01B. Antineoplastic antimetabolites are "antimetabolites that are useful in cancer chemotherapy."[4]

Folic acid analogues
ATC/DDD group L01BA. Examples include:

is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA."[5]

Purine analogues
ATC/DDD group L01BB. Examples include: is an "antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

Pyrimidine analogues
ATC/DDD group L01BC. Examples include: "pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties."[7] {{r|fluorouracil {{r|tegafur {{r|carmofur {{r|gemcitabine {{r|capecitabine {{r|azacitidine {{r|decitabine

Plant alkaloids and other natural products
ATC/DDD group L01C.

Vinca alkaloids and analogues
ATC/DDD group L01CA.

Podophyllotoxin derivatives
ATC/DDD group L01CB.

Colchicine derivatives
ATC/DDD group L01CC.

Taxanes
ATC/DDD group L01CD.

Other plant alkaloids and natural products
ATC/DDD group L01CX.

Cytotoxic antibiotics and related substances
ATC/DDD group L01D.

Actinomycines
ATC/DDD group L01DA.

Anthracyclines and related substances
ATC/DDD group L01DB.

Other cytotoxic antibiotics
ATC/DDD group L01DC.

Other antineoplastic agents
ATC/DDD group L01X.

Platinum compounds
ATC/DDD group L01XA.

Methylhydrazines
ATC/DDD group L01XB.

Monoclonal antibodies
ATC/DDD group L01XC. Examples include:

Anti-EGRF
an "antibody that blocks receptors for epidermal growth factor (Entrez protein); approved for advanced colon cancer".[8]

Anti-EpCAM
is monclonal antibody against EpCAM (Entrez protein). Edrecolomab is a "anticolorectal carcinoma antibody for treatment of advanced colorectal carcinoma".[9]

Anti-ERBB2
"HER2 (Entrez protein) antibody that lengthens remission time in metastatic breast cancer."

Anti-CD3 and anti-EpCAM
Is a monoclonal antibody against CD3 (Entrez protein)and EpCAM (Entrez protein). "Extracorporeal PBMNC coating with catumaxomab may be an option to control intravascular cytokine release induced by therapeutic antibodies".[11]

Anti-MS4A1 (CD20 antigen)
is a "genetically engineered anti-CD20 (Entrez protein) antibody for the treatment of B-cell lymphoma".[12]

Anti-SIGLEC3 (CD33)
is an "anti-CD33 (Entrez protein) antibody calicheamicin conjugate".[13]

Anti-CD52
* Alemtuzumab is a "a therapeutic antibody directed against the CDw52 antigen (Entrez protein) expressed by the lymphocytes and has proven lytic abilities both in vitro and in vivo; has been sequenced".[14]

Anti-VEGF
is an "anti-VEGF (Entrez protein) monoclonal antibody consisting of humanized murine antibody with antigen-binding, complementary-determining regions from murine VEGF".[15]

Sensitizers used in photodynamic/radiation therapy
ATC/DDD group L01XD.

Protein kinase inhibitors
ATC/DDD group L01XE