Granulocyte colony-stimulating factor

Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein of MW 25 kDa, which stimulate the production of neutrophils and their precursors, and is used to treat neutropenia.

It is a glycoprotein containing disulfide bonds, which has a molecular waight of 25 kilodalton (kDa) Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.

It is not the same agent as granulocyte-macrophage colony-stimulating factor (GM-CSF), the synthetic version of which is filagastrim.