Cytochrome P-450 CYP2C19

In biology, the cytochrome P-450 CYP2D19 is an isoenzyme of cytochrome P-450. 2-6% of anglos and 15-25% of asians are poor metabolizers of drugs that use the CYP2C19 isoenzyme. More recently, a study suggests that 30% of patients may have a reduced-function allele.

CYP2C19 polymorphism affects response to clopidogrel. CYP2C19 loss-of-function alleles are associated with more cardiovascular events. Concomitant proton pump inhibitors, which are also metabolized by CYP2C19, may (especially inhibitors other than pantoprazole ) or may not increase adverse cardiac events.