Apolipoprotein C-III

In medicine and physiology, apolipoprotein C-III is apolipoprotein that is "a 9-kDa protein component of very-low-density lipoproteins and chylomicron remnants. Apo C-III, synthesized in the liver, is an inhibitor of lipoprotein lipase. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (receptors, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of sialic acid (Apo C-III-0, Apo C-III-1, and Apo C-III-2)."

Fatty liver and steatohepatitis may be caused by the single-nucleotide polymorphisms rs2854116 (c.455T>C) and rs2854117 (c.482C>T)  of apolipoprotein C-III which are also associated with insulin resistance and hypertriglyceridemia.