First-generation antidepressant

First-generation antidepressants includes the two drug classes used widely to treat depression, the tricyclic antidepressants and the monoamine oxidase inhibitors (MAOI), and heterogeneity of chemical form and pharmacological action. While the MAOIs are relatively little used due to their dangerous food and drug interactions, tricyclics remain in use for depression, and also have a number of other applications such as the management of chronic pain.